We can stop aging by switching off the crucial enzyme responsible for cellular senescence.
Scientific research shows that we are a step closer to a longer and healthier physical life. It looks like science is able to reverse the so far unavoidable natural aging process of cell tissue.
The Korea Advanced Institute of Science and Technology (KAIST) made this exiting news public.
KAIST scientists explained that simulations show that we can stop and reverse cellular senescence.
They investigated the enzyme called PDK1 in incubated senescent skin fibroblasts and three-dimensional skin equivalent tissue models.
The important findings by the team brings a closer look into the very complex mechanism of cellular senescence and present a potential therapeutic strategy to tackle age-related diseases associated with the accumulation of senescent cells.
Enzyme PDK1 plays a key role. This enzyme is crucial as it comes to the aging process of cells. The researchers discovered that blocking PDK1 would lead to the inhibition of two downstream signaling molecules, which in turn restore the cells’ ability to enter back into the cell cycle. Notably, the cells retained their capacity to regenerate wounded skin without proliferating in a way that could lead to malignant transformation.
Professor Kwang-Hyun about the findings: “Our research opens the door for a new generation that perceives aging as a reversible biological phenomenon”
Cells have the ability to responding to a variety of factors, such as oxidative stress, DNA damage, and shortening of the telomeres capping the ends of chromosomes, by entering a stable and persistent exit from the cell cycle.
This cellular senescence is unmissable because it prevents damaged cells from proliferating and turning into cancer cells.
On the other hand, this natural process plays a dominant part to aging and particularly age related diseases.
The research show undebatable evidence that we can reverse cellular senescence.
However, the laboratory approaches used thus far also impair tissue regeneration or have the potential to trigger malignant transformations.
The scientists recommend further investigations in organs and organisms to determine the full impact of PDK1 inhibition. Since the gene that codes for PDK1 is overexpressed in some cancers, the scientists expect that inhibiting it will have both anti-aging and anti-cancer effects.